General information
| Name: Rona |
| Surname: Ramsay |
| E-mail: rrr@st-andrews.ac.uk |
| Cell phone number with international prefix: +44 1334 463411 (office) |
| Country: UK |
| Affiliation: University of St Andrews |
| Gender: F □ x |
| Year of the PhD title: 1977 |
| Personal web page: http:// |
| Previous COST participation: Yes □ D64 and CM1103 |
List of 10 selected publications within last 5 years
| 1. Nikolic,K., Lazaros Mavridis, Oscar M Bautista-Aguilera, Jose Marco-Contelles, Holger Stark, Maria do Carmo Carreiras, Ilaria Rossi, Paola Massarelli, Danica Agbaba, Rona R Ramsay, John B. O. Mitchell (2015) Predicting targets of compounds against neurological diseases using cheminformatic methodology. Journal of Computer-Aided Molecular Design 29 (2), 183-198. DOI: 10.1007/s10822-014-9816-1 |
| 2. Benek,O, Ondrej Soukup, Marketa Pasdiorova, Lukas Hroch, Vendula Sepsova, Petr Jost, Martina Hrabinova, Daniel Jun, Kamil Kuca, Dominykas Zala, R. R. Ramsay, José Marco-Contelles, Kamil Musilek. (2015) “Design, synthesis and in vitro evaluation of indolotacrine analogues as multi-target-directed ligands for the treatment of Alzheimer’s disease” ChemMedChem. DOI: 10.1002/cmdc.201500383 |
| 3. Malcomson,T, Kemal Yelekci, Maria Teresa Borrello, A. Ganesan, Elena Semina, Norbert De Kimpe, Sven Mangelinckx, and Rona R. Ramsay (2015) cis-Cyclopropylamines as mechanism-based inhibitors of Monoamine Oxidases. FEBS J. 282 (16) 3190-3198 DOI: 10.1111/febs.13260 |
| 4. Bautista-Aguilera,OM, Abdelouahid, Samadi, Mourad Chioua, Katarina Nikolic, Slavica Filipic, Danica Agbaba, Elena Soriano, Lucía de Andrés, María Isabel Rodríguez-Franco, Stefano Alcaro, Rona R. Ramsay, Francesco Ortuso, Matilde Yañez, and José Marco-Contelles (2014) N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual Inhibitor. J. Med. Chem. 57 (24) 10455-10463. DOI: 10.1021/jm501501a |
| 5. Messina,A, Simona Reina, Francesca Guarino, Andrea Magrì, Flora Tomasello, Richard E. Clark, Rona R. Ramsay and Vito De Pinto (2014) Live cell interactome of the human Voltage Dependent Anion Channel 3 (VDAC3) revealed in HeLa cells by Affinity Purification Tag Technique. Molecular BioSystems, 10 (2014) 2134-2145. DOI:10.1039/c4mb00237g |
| 6. Esteban,G, Allan J, Samadi A, Romero A, Pino JD, Herreroa R, Martínez-Murilloa, R., Mattevi, A., Unzeta, M., Marco-Contelles, J., Binda, C., and Ramsay, R. R. (2014) Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by the multi-target ASS234 compound and biological assessment for its potential use in Alzheimer’s disease. Biochim. Biophys. Acta (Proteins and Proteomics), 1844 (2014) 1104–1110. http://dx.doi.org/10.1016/j.bbapap.2014.03.006 |
| 7. Juárez-Jiménez,J., M. E. Mendes, C. Martins, D.B. Silva, J. Marco-Contelles, M. C. Carreiras, F.J. Luque and R.R. Ramsay (2014). Exploring the structural basis of the selective inhibition of monoamine oxidase A by dicarbonitrile aminoheterocycles: Role of Asn181 and Ile335 validated by spectroscopic and computational studies. Biochim. Biophys. Acta (Proteins and Proteomics), 1844: 389–397. http://dx.doi.org/10.1016/j.bbapap.2013.11.003 |
| 8. Ramsay,R.R.,(2013) Monoamine Oxidases: The Proteins as Targets in Medicinal Chemistry and Drug Discovery. Curr. Topics Med. Chem. 12: 2189-2209. |
| 9. Ramsay,R.R., A. Olivieri, A. Holt (2011) An improved approach to steady-state analysis of monoamine oxidases. J. Neural Transm. 118:1003–1019. DOI 10.1007/s00702-011-0657-y |
| 10. Dixon Clark,S.E. and R.R. Ramsay (2010) Dietary inhibitors of monoamine oxidase A. J. Neural Transm. 118:1031–1041. DOI 10.1007/s00702-010-0537-x. |
Main skills and expertise (up to 5)
| 1. Enzymology |
| 2. Protein purification |
| 3. Mitochondrial bioenergetics |
| 4. UV-vis spectrocospy |
| 5. Cell-based assays |
Main equipment/facilities available in the participants’ lab (up to 5)
| 1. Spectrophotometers (UV-vis and stopped-flow) |
| 2. Plate readers |
| 3. Protein purification (centrifuges, fraction collectors etc) |
| 4. Proteomics (access charge) |
| 5. “Seahorse” bioenergetics analyzer (access charge) |
Short personal activity proposal for the COST Action CA15135 (max 1000 characters)
| The Ramsay group uses purified monoamine oxidase for chemical studies, applying biochemical techniques for kinetics and mechanism to validate theoretical work. Screening assays on a range of membrane bound enzymes are also available. We are currently pioneering a cell-based neuronal model for screening mitochondrially-targetted compounds and aim to run differential proteomics to identify factors underlying the effects of selected key proteins on cell survival.
Through COST Actions, I can share my expertise in biological assays, and enjoy collaborations to integrate theory and experiment, and chemistry and biology.
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Work Group preference: score from 1 (preferred) to 4 (not preferred)
| Work Group of the CA15135 COST Action | Score |
| WG1: Development of new chemical entities | 3 |
| WG2: Selection of biological targets and assessment of biological data | 1 |
| WG3: Development of chemical databases | 4 |
| WG4: Development of Computational methods for multiple ligand design and discovery | 2 |
