General information
| Name: Dariusz |
| Surname: Matosiuk |
| E-mail: darek.matosiuk@umlub.pl |
| Cell phone number with international prefix: +48 501281474 |
| Country: Poland |
| Affiliation: Faculty of Pharmacy, Medical University of Lublin |
| Gender: F □ M X |
| Year of the PhD title: 1991 |
| Personal web page: http:// |
| Previous COST participation: No □ Yes X |
List of 10 selected publications within last 5 years
| 1. Chem. Rev. 113 (7) (2013), 4905-4979. Thirumurugan P., Matosiuk D., Jóżwiak K.: Click chemistry reaction for diverse biological applications. |
| 2. Curr, Med. Chem. 20 (27) (2013), 3317-3338. Skrzypczak M., Kapka-Skrzypczak L., Cyranka M., Treeck O., Wróbel A., Matosiuk D.: Nuclear estrogen receptors co-activation mechanisms. |
| 3. J. Pharm. Biomed. Anal. 87 (2014), 313-325. Drączkowski P., Matosiuk D., Jóźwiak K.: Isothermal titration calorimetry in membrane protein research. |
| 4. Bioorg. Med. Chem. 22 (2) (2014), 787-795. Kaczor A.A., Karczmarzyk Z., Fruziński A., Pihlaja K., Sinkkonen J., Viinamaki K., Kronbach Ch., Unverferth K., Poso A., Matosiuk D.: Structural studies, homology modeling and molecular docking of novel noncompetitive antagonists of GluK1/GluK2 receptors. |
| 5. Bioorg. Med. Chem. 22 (24) (2014), 6846-6856. Jozwiak K., Targowska-Duda K., Kaczor A., Kozak J., Ligeza A., Szacon E., Wrobel T., Budzynska B., Biala G., Fornal E., Poso A., Wainer W.I., Matosiuk D.: Synthesis, in vitro and in vivo studies, and molecular modeling of N-alkylated dextrometorphane derivatives as non-competitive inhibitors of a3b4 nicotinic acetylcholine receptor. |
| 6. J. Chem. Inf. Model. 55 (11) (2015), 2421-2434. Bartuzi D., Kaczor A.A., Matosiuk D.: Activation and allosteric modulation of human mu opioid receptor in molecular. |
| 7. Arch. Biochem. Biophys. 592 (2016), 1-4. Janik E., Bednarska J., Zubik M., Sowiński K., Luchowski R., Grudziński W., Matosiuk D., Gruszecki W.I.: The xanthophyll cycle pigments, violaxanthin and zeaxanthin, modulate molecular organization of the photosynthetic antenna complex LHCII. |
| 8. Biochem. Biophys. Acta–Gen. Subj. 1860 (5) (2016), 967-974. Drączkowski P., Tomaszuk A., Halczuk P., Strzemski M., Matosiuk D., Jóźwiak K.: Determination of affinity and efficacy of acetylcholinesterase inhibitors using isothermal titration calorimetry. |
| 9. J. Chem. Inf. Model. (2016), accepted for publivation. Bartuzi D., Kaczor A.A., Matosiuk D.: Interplay between two allosteric sites and their influence on agonist binding in human mu opioid receptor. |
| 10. J. Enzyme Inhib. Med. Chem. (2016), accepted for publication. Wróbel T., Kiełbus M., Kaczor A.A., Krystof V., Karczmarzyk Z., Wysocki W., Fruzinski A., Król S., Grabarska A., Stepulak A., Matosiuk D.: Discovery of nitroaryl urea derivatives with antiproliferative properties. |
Main skills and expertise (up to 5)
| 1. Organic and heterocyclic synthesis. |
| 2. Organic compounds structure elucidation. |
| 3. Molecular modeling of ligand-protein interactions |
| 4. Physicochemical properties affecting bioavailability. |
| 5. Thermodynamics of ligand-protein interactions. |
Main equipment/facilities available in the participants’ lab (up to 5)
| 1. 300 (C,H) and 600 (multinuclear)MHz NMR |
| 2. UPHPLC with different detectors (MS, CDI, corona, UV) |
| 3. Microcalorymetry titration (MCT), surface plasmon resonance (SPR), patch-clamp units |
| 4. IR/Raman miscroscops, confocal microscop |
| 5. 96 and 264-cores clasters for molecular modeling and molecular dynamics calculation |
Short personal activity proposal for the COST Action CA15135 (max 1000 characters)
| Within the COST Action CA15135 I would be interested in discussing possibility of multitarget and multieffect ligands development with some special interest in:
1) Combining antinociceptive and antidepressant activity; 2) Allosteric and dualsteric action on opioid and dopaminergic receptors; 3) Development of the computation methods for multiple ligand design and discovery. Natural continuation of the following points of interest would be also involvement in development of chemical and biological databases. |
Work Group preference: score from 1 (preferred) to 4 (not preferred)
| Work Group of the CA15135 COST Action | Score |
| WG1: Development of new chemical entities | X |
| WG2: Selection of biological targets and assessment of biological data | |
| WG3: Development of chemical databases | |
| WG4: Development of Computational methods for multiple ligand design and discovery | X |
