3.       D. Staneva, E. Vasileva-Tonkova, M. S. I. T. Makki, T. R. Sobahi, R. M. Abdulrahman, A. M. Asiri, I. Grabchev, Synthesis, photophysical and antimicrobial activity of new water soluble ammonium quaternary benzanthrone in solution and in polylactide film, Journal of Photochemistry and Photobiology B: Biology, 2015, 143, 44-51

4.       D. Staneva, E. Vasileva-Tonkova, M. S.I. Makki, T. R. Sobahi, R. M. Abdеl-Rahman, I. H. Boyaci, A.M. Asiri, I. Grabchev, Synthesis and spectral characterization of a new PPA dendrimer modified with 4-bromo-1,8-naphthalimide and in vitro antimicrobial activity of its Cu(II) and Zn(II) metal complexes, Tetrahedron, 71, 2015, 1080-1087

5.      D. Staneva, D. Atanasova, E. Vasileva-Tonkova, V. Lukanova, I. Grabchev,  A cotton fabric modified with a hydrogel containing ZnO nanoparticles. Preparation and properties study, Applied Surface Science, 2015, 345, 72-80

6.       I. Grabchev, S.Yordanova, E. Vasileva-Tonkova, P. Bosch, S. Stoyanov, Poly(propylenamine) dendrimers modified with 4-amino-1,8- naphthalimide: Synthesis, characterization and in vitro microbiological tests of their Cu(II) and Zn(II) complexes, Inorganica Chimica Acta 438 (2015) 179–188

7.       S. Yordanova, H. T. Temiz, I.H. Boyaci, S. Stoyanov, E. Vasileva-Tonkova, A. M. Asiri, I. Grabchev, Synthesis, characterization and in vitro antimicrobial activity of a new blue fluorescent Cu(II) metal complex of bis-1,8-naphthalimide, Journal of Molecular Structure 1101 (2015) 50-56.

Dendrimer molecules contain a large number of closely located functional groups in their structure. If these groups are functionalized with a biologically active substance, it can be expected the increase in biological activity of the dendrimers as compared with the compounds of low molecular weight.

During this campaign we plan to accomplish the following tasks:

1.      Synthesis of dendrons and dendrimers with antimicrobial properties

2.      Synthesis of metallodendrimers with antimicrobial properties

3.      Synthesis and study of thin films of polylactide with incorporated low molecular weight compounds and dendrimers with antimicrobial activityPreparation and study of textile materials with antibacterial activity

4.      Microbiological studies of the newly synthesized compounds

The antimicrobial activity of the newly synthesized compounds and composite materials based on polylactide and textiles will be explored in vitro against different model Gram (+) and Gram (-) bacteria and fungal strains by the method of diffusion in solid nutrient medium and quantified by determining the minimum inhibitory concentration (MIC) and the minimum bactericide concentration (MBC). In assessing the activity of the substances will be used standards – antibiotics with known effectiveness against relevant microorganisms. More detailed studies with selected dendrimeric compounds will be carried out related to study their effect on the growth and cell membrane properties of model Gram (+) and Gram (-) bacterial strains.