General information
| Name: Eddy |
| Surname: Sotelo |
| E-mail: e.sotelo@usc.es |
| Cell phone number with international prefix: +34-639888525 |
| Country: Spain |
| Affiliation: Santiago de Compostela University |
| Gender: F □ M ý |
| Year of the PhD title: 2000 |
| Personal web page: http://www.usc.es/ciqus/en/groups/combiomed |
| Previous COST participation: No □ Yes ý |
List of 10 selected publications within last 5 years
| 1. J. Med. Chem., 2016, 59, 1967-1983 |
| 2. Fut. Med. Chem., 2015, 7, 1373-1380 |
| 3. J. Med. Chem., 2011, 54, 457-471 |
| 4. ChemBioChem. 2014, 15, 1471-1480 |
| 5. ACS Med. Chem. Lett., 2013, 4, 1031-1036 |
| 6. Eur. J. Med. Chem., 2013, 59, 235-242 |
| 7. J. Org. Chem., 2013, 78, 4402-4409 |
| 8. J. Org. Chem., 2015, 80, 1533-1549 |
| 9. J. Cat., 2016, 334, 110-115 |
| 10. ACS Comb. Sci., 2014, 16, 403-411 |
Main skills and expertise (up to 5)
| 1. Lead generation and Lead Optimization using Multicomponent Reactions |
| 2. Multicomponent-Assisted Multi-target Optimization |
| 3. Development and Optimization of Molecular Probes (Fluorescent ligands, bivalent ligands . . ) |
| 4. Library Generation |
| 5. Experimental validation of Computational predictions |
Main equipment/facilities available in the participants’ lab (up to 5)
| 1. Library of Heterocyclic Compounds (≈ 3000 Cpds) Assembled by Multicomponent Reactions |
| 2. State of the Art Synthesis Laboratory (Microwave Synth., ComBiFlash, etc.). |
| 3. Portfolio of near 50 Multicomponent Reactions For Drug Discovery Programs |
| 4. Analytical and Structural Facilities (NMR, Mass, HPLC, Circular Dichroism) |
| 5. |
Short personal activity proposal for the COST Action CA15135 (max 1000 characters)
|
The research proposal of our research group focus on the following points:
1- We propose to cede part of our library of heterocyclic compounds (≈ 3000 Cpds) to the computational and biological/pharmacological groups interested to collaborate. Our library is a collection of heterocyclic compounds (≈ 3000 Cpds) assembled by multicomponent reactions.
2- We propose to collaborate with computational groups in the synthesis and validation of virtual screening predictions.
3- We propose to collaborate in the implementation of mul-titarget optimization process of previously identified hit compounds.
4- We propose to synthesize and optimize ad hoc molecular probes (e.g. fluorescent ligands, homo-bivalent, hetero-bivalent or bitopic ligands, etc.).
5- We could host Ph D. students and post-doctoral researchers, providing training in MCR chemistry and other advanced synthetic methodologies.
6- We could organize one of the actions meeting in Santiago de Compostela (Spain). |
Work Group preference: score from 1 (preferred) to 4 (not preferred)
| Work Group of the CA15135 COST Action | Score |
| WG1: Development of new chemical entities | 1 |
| WG2: Selection of biological targets and assessment of biological data | 4 |
| WG3: Development of chemical databases | 2 |
| WG4: Development of Computational methods for multiple ligand design and discovery | 2 |
